|
KMID : 1101420190510040504
|
|
Korean Journal of Clinical Laboratory Science
2019 Volume.51 No. 4 p.504 ~ p.513
|
|
|
Antidiabetic and Antioxidative Effects of Bitter Melon on Streptozotocin-induced Diabetic Rats
|
|
Kim Yeon-Jeoung
Wang Soo-Kyoung
Park Un-Kyu
Oh Ji-Hye
Hwang Seok-Youn
|
|
|
Abstract
|
|
|
|
The purpose of this study was to determine the antidiabetic and antioxidative effects of Bitter melon on streptozotocin-induced diabetic rats. The normal and the control groups were fed an AIG -93M diet, and the Bitter melon groups were fed 1%, 2% and 3% Bitter melon powder. After two weeks, the control and the experimental group were induced to a diabetic state with the administration of streptozotocin. The blood glucose control and antioxidant activity were analyzed after the animals were sacrificed. The blood glucose levels of all the Bitter melon groups were lower than those of the control group, and the 2% Bitter melon group showed significantly lower blood glucose levels than those of the control group. Serum Triglyceride and HDL-cholesterol of the 2%, and 3% Bitter melon groups were significantly lower than those of the control group. The total cholesterol levels of the bitter melon groups were significantly lower than those of the control group. The serum insulin levels of the induced groups were significantly lower than those of the normal group. The HbA1c levels of the 2% and 3% Bitter melon groups were significantly lower than those of the control group. For the level of antioxidant enzymes in the liver tissues, the 2% Bitter melon group was significantly higher than that of the control group. These results show the antidiabetic and antioxidative effects of Bitter melon for the prevention and treatment of diabetes.
|
|
|
KEYWORD
|
|
|
Antioxidant enzymes, Bitter melon, Blood glucose, Diabetes melitus, HbA1c
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|